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Xarelto
(rivaroxaban) is a FXa inhibitor indicated for the prevention of deep
vein thrombosis which may lead to pulmonary embolism in patients
undergoing knee or hip replacement surgery. Xarelto (rivaroxaban) is not
available in the U.S. in generic form. The most common adverse
reactions with Xarelto are bleeding complications, including major
bleeding events. Other side effects of Xarelto include fainting,
itching, pain in your arms or legs, muscle pain, and muscle spasms.
Xarelto (rivaroxaban) is supplied in 10 mg strength tablets. The
recommended dose of Xarelto is 10 mg taken orally once daily with or
without food. The initial dose should be taken at least 6 to 10 hours
after surgery once hemostasis has been established. Dosing for pregnant
women has not been established. Some antibiotics, antifungal
medications, anticoagulants, blood thinners, NSAIDs, and aspirin may
have adverse interactions when used with Xarelto. The anticoagulant
effect of Xarelto cannot be monitored with standard laboratory testing
nor readily reversed. Xarelto should be used with caution in pregnant
women and only if the potential benefit justifies the potential risk to
the mother and fetus. Xarelto dosing in pregnancy has not been studied.
It is not known if Xarelto is excreted in human milk. Because many drugs
are excreted in human milk and because of the potential for serious
adverse reactions in nursing infants from Xarelto, a decision should be
made whether to discontinue nursing or discontinue the drug, taking into
account the importance of the drug to the mother. Xarelto side effects
that are severe are spinal hematomas that may develop after spinal
surgery with this drug. Co-use with Ketoconazole, Clarithromycin,
erythromycin, and other similar drugs may increase the risk of bleeding.
Safety and effectiveness has not been determined in pediatric patients.
Our Xarelto Side Effects Drug Center provides a comprehensive view of
available drug information on the potential side effects when taking
this medication.
This is not a complete list of side effects and
others may occur. Call your doctor for medical advice about side
effects. You may report side effects to FDA at 1-800-FDA-1088.
Xarelto in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these
signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using rivaroxaban and call your doctor at once if you have a serious side effect such as:
- easy
bruising, unusual bleeding (nose, mouth, vagina, or rectum), bleeding
from wounds or needle injections, any bleeding that will not stop;
- heavy menstrual periods;
- headache, dizziness, weakness, feeling like you might pass out;
- red or pink urine;
- black or bloody stools, coughing up blood or vomit that looks like coffee grounds;
- numbness, tingling, or muscle weakness (especially in your legs and feet); or
- loss of movement in any part of your body.
Less serious side effects may include:
- muscle pain;
- itching; or
- pain in your arms or legs.
This
is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects.
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